Selected reading

Extensive pre-clinical & clinical experience

Nearly four hundred scientific reports have been published on the chemistry, biological properties and clinical performance of the CBAS® technology by groups from all over the world. Below is a selection of papers representative of what has been published throughout the years.

For a complete list of published scientific papers, please download the latest reference list.

Historic
A NEW NON-THROMBOGENIC SURFACE PREPARED BY SELECTIVE COVALENT BINDING OF HEPARIN VIA A MODIFIED REDUCING TERMINAL RESIDUE
O. Larm et al., Med. dev., Art. Org., 11:2-3 (1983) 161-173.

A NEW METHOD FOR COVALENT COUPLING OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS TO SUBSTANCES CONTAINING PRIMARY AMINOGROUPS
J. Hoffman et al., Carbohydr. Res., 117 (1983) 328-331.

Basic
ON THE BLOOD COMPATIBILITY OF END-POINT IMMOBILIZED HEPARIN
P. Olsson et al., J. Biomater. Sci. Polymer Edn., 11:11 (2000) 1261-1273.

HEMOCOMPATIBILITY OF HEPARIN-COATED SURFACES AND THE ROLE OF SELECTIVE PLASMA PROTEIN ADSORPTION
N. Weber et al., Biomaterials 2002, 23 (2), 429-439

MECHANISM OF COMPLEMENT ACTIVATION DURING EXTRACORPOREAL BLOOD-BIOMATERIAL INTER-ACTION: EFFECTS OF HEPARIN COATED AND UNCOATED SURFACES
R. Kopp et al., ASAIO J 48:6 (2002) 598-605

Vascular grafts
IMPROVEMENTS IN GORE-TEX® VASCULAR GRAFT PERFORMANCE BY CARMEDA®  BIOACTIVE SURFACE HEPARIN IMMOBILIZATION
P.C. Begovac et al., Eur J Vasc Endovasc Surg 25(2003) 423-437

SMALL CALIBER HEPARIN-COATED e-PTFE GRAFTS REDUCE PLATELET DEPOSITION AND NEOINTIMAL HYPERPLASIA IN A BABOON MODEL
P. Lin et al., J Vasc Surg 39:6 (2004) 1322-1328

EVALUATION OF PLATELET DEPOSITION AND NEOINTIMAL HYPERPLASIA OF HEPARIN-COATED SMALL-CALIBER EPTFE GRAFTS IN A CANINE FEMORAL ARTERY BYPASS MODEL(1)
P. Lin et al., Chen, C.; J Surg Res 118:1 (2004) 45-52

INFRAINGUINAL ePTFE VASCULAR GRAFT WITH BIOACTIVE SURFACE HEPARIN BONDING. FIRST CLINICAL RESULTS
K. P. Walluscheck et al., J Cardiovasc Surg (Torino) 46:4 (2005) 425-430

HEPARIN IMMOBILIZATION REDUCES THROMBOGENICITY OF SMALL-CALIBER EXPANDED POLYTETRAFLUOROETHYLENE GRAFTS.
J.M. Heyligers et al., J Vasc Surg 43:3 (2006) 587-591.

Extracorporeal circulation
SUPERIOR HEMODYNAMICS IN LEFT HEART BYPASS WITHOUT SYSTEMIC HEPARINIZATION
L.K. von Segesser et al., J. Cardio-thorac. Surg., 4 (1990) 384-389.

HEPARIN COATED VERSUS NON-COATED SURFACES FOR EXTRACORPOREAL CIRCULATIONS
K. Mottaghy et al., 17th Congr. ESAO, Bologna, Italy, Int. J. Artif. Organs., 14:11 (1990) 721-728.

BIOCOMPATIBILITY OF EXTRACORPOREAL CIRCULATION: IN VITRO COMPARISON OF HEPARIN COATED AND UNCOATED OXYGENATOR CIRCUITS
V. Videm et al., Cardiovasc. Surg., 101 (1991) 654-660.

EXTRACORPOREAL LUNG ASSIST WITH HEPARIN-COATED SYSTEMS
R. Rossaint et al., J. Artif. Organs,, 15:1 (1992) 29-34.

PROGRESS IN VENO-VENOUS LONG-TERM BYPASS TECHNIQUES FOR THE TREATMENT OF ARDS
M. Knoch et al., J. Artif. Org., 15:2 (1992) 103-108.

EXTRACORPOREAL MEMBRANE OXYGENATION: PRELIMINARY RESULTS IN PATIENTS WITH POSTCAR-DIOTOMY CARDIOGENIC SHOCK
G. J. Magovern et al., Ann. Thorac. Surg., 57 (1994) 1462-1471.

CLINICAL EFFECTS OF THE HEPARIN COATED SURFACE IN CARDIOPULMONARY BYPASS
S. Svenmarker et al., J. Carido-thorac. Surg., 11 (1997) 957-964.

A CLOSED PERFUSION SYSTEM WITH HEPARIN COATING AND CENTRIFUGAL PUMP IMPROVES CARDIO-PULMONARY BYPASS BIOCOMPATIBILITY IN ELDERLY PATIENTS
L. Lindholm et al., Ann Thorac Surg 78:6 (2004) 2131

Stents
REDUCTION IN THROMBOTIC EVENTS WITH HEPARIN-COATED PALMAZ-SCHATZ STENTS IN NORMAL PORCINE CORONARY ARTERIES
P.A. Hårdhammar et al., Circulation, 93 (1996) 423-430.

HEPARIN-COATED PALMAZ-SCHATZ STENTS IN HUMAN CORONARY ARTERIES. EARLY OUTCOME OF THE BENESTENT-II PILOT STUDY.
P. W. Serruys et al., Circulation, 93 (1996) 412-422.

IN VIVO MODEL OF INTRACRANIAL STENT IMPLANTATION: A PILOT STUDY TO EXAMINE THE HISTOLOGI-CAL RESPONSE OF CEREBRAL VESSELS AFTER RANDOMIZED IMPLANTATION OF HEPARIN-COATED AND UNCOATED ENDOLUMINAL STENTS IN A BLINDED FASHION
E. I Levy at al., J Neurosurg 98:3 (2003) 544-553

CORONARY INTERVENTION WITH A HEPARIN-COATED STENT AND ASPIRIN ONLY
P. N. Ruygrok et al., J Invasive Cardiol 15:8 (2003) 439-441

REDUCTION OF SUBACUTE STENT THROMBOSIS (SAT) USING HEPARIN-COATED STENTS IN A LARGE SCALE, REAL WORLD REGISTRY
V. Gupta et al., J Invasive Surg 16:6 (2004) 304-310

Catheters
SURFACE HEPARINIZATION OF CENTRAL VENOUS CATHETERS REDUCES MICROBIAL COLONIZATION IN VITRO AND IN VIVO: RESULTS FROM A PROSPECTIVE, RANDOMIZED TRIAL
P. Appelgren et al., Crit. Care Med., 24:9 (1996) 1482-1489.

EFFECT OF COVALENTLY BOUND HEPARIN COATING ON PATENCY AND BIOCOMPATIBILITY OF LONG-TERM INDWELLING CATHETERS IN THE RAT JUGULAR VEIN
P.Foley et al. Comparative Medicine 52 (2002) 243-248

For a complete list of publications, please download:

CBAS reference list June 2010 (PDF 150k)